| Alzheimer’s disease patient-derived high-molecular weight tau impairs bursting in hippocampal neurons |
| July 10, 2025 |
| Samuel.Harris,R.Ellingford,Jana Hartmann,M.Kehring,M.Rajani,D.Graykowski,N.Quittot,D.Sivasankaran,C.Commins,Z.Fan,SurayaA.Bond,FredWolf,D.Dupret,J.Dolan,Arthur Konnerth,A.Neef,T.Hyman,Marc Aurel Busch |
| Cell |
 In mouse models, tau impairs neuronal complex spike bursting and associated network processes in hippocampus CA1 alongside CaV2.3 downregulation. Soluble high-molecular-weight tau species drive these impairments, as lowering levels rectifies deficits and AD patient-derived extracts selectively compromise burst generation.
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