| Two types of functionally distinct Ca2+ stores in hippocampal neurons
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| July 19, 2019
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| Hsing-Jung Chen-Engerer, Jana Hartmann, Rosa Maria Karl, Jun Yang, Stefan Feske, Arthur Konnerth
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| Nature Communication
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 It is widely assumed that inositol trisphosphate (IP3) and ryanodine (Ry) receptors share the same Ca2+ pool in central mammalian neurons. We now demonstrate that in hippocampal CA1 pyramidal neurons IP3- and Ry-receptors are associated with two functionally distinct intracellular Ca2+ stores, respectively. While the IP3-sensitive Ca2+ store refilling requires Orai2 channels, Ry-sensitive Ca2+ store refilling involves voltage-gated Ca2+ channels (VGCCs). Our findings have direct implications for the understanding of function and plasticity in these central mammalian neurons.
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