| Han Qin , Ling Fu , Xiang Liao , Jian Lu , Wenjing He , Shanshan Liang , Kuan Zhang , Ruijie Li , Jiwei Yao , Junan Yan , Hao Chen , Hongbo Jia , Benedikt Zott , Arthur Konnerth , Xiaowei Chen
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 The ability to remember and to navigate to safe places is necessary for survival. Place navigation is known to involve medial entorhinal cortex (MEC)-hippocampal connections. However, learning-dependent changes in neuronal activity in the distinct circuits remain unknown. Here, by using optic fiber photometry in freely behaving mice, we discovered the experience-dependent induction of a persistent-task-associated (PTA) activity. This PTA activity critically depends on learned visual cues and builds up selectively in the MEC layer II-dentate gyrus, but not in the MEC layer III-CA1 pathway, and its optogenetic suppression disrupts navigation to the target location. The findings suggest that the visual system, the MEC layer II, and the dentate gyrus are essential hubs of a memory circuit for visually guided navigation.
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